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Name	LGC
Type	Genome Assembly and Annotation
Developers	Guangyu Wang, Lina Ma, Zhang Zhang
Description	LGC is a novel algorithm for identifying lncRNAs that is able to accurately distinguish lncRNAs from protein-coding RNAs in a cross-species manner without any prior knowledge. As validated on large-scale empirical datasets, comparative results show that LGC outperforms existing algorithms by achieving higher accuracy, well-balanced sensitivity and specificity, and is robustly effective (>90% accuracy) in discriminating lncRNAs from protein-coding RNAs across diverse species that range from plants to mammals. To our knowledge, this study, for the first time, differentially characterizes lncRNAs and protein-coding RNAs based on feature relationship, which is further applied in computational identification of lncRNAs. Taken together, our study represents a significant advance in characterization and identification of lncRNAs and LGC thus bears broad potential utility for computational analysis of lncRNAs in a wide range of species.
Downlaod	https://ngdc.cncb.ac.cn/biocode/tools/BT000004
Online Link	https://ngdc.cncb.ac.cn/lgc/
Article	https://academic.oup.com/bioinformatics/article/35/17/2949/5288512?login=false
Cite Count	60